Luteolin protects PC-12 cells from H 2 O 2 -induced injury by up-regulation of microRNA-21.
Biomedicine & Pharmacotherapy(2019)
Abstract
•Luteolin protects PC-12 cells from H2O2-induced oxidative injury.•Luteolin up-regulates the expression of miR-21 in H2O2-treated PC-12 cells.•miR-21 participates in the protective effect of luteolin on PC-12 cell injury.•Luteolin activates PI3K/AKT pathway and inactivates PDCD4/p21 pathway.•Luteolin also protects rBMECs from H2O2-induced oxidative injury.
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Key words
ICVD,ROS,MDA,Trx-1,miRNAs,miR-21,rBMECs,PEA,RPMI,FBS,DMSO,NC,qRT-PCR,CCK-8,DCFH-DA,PTEN,PI3K,AKT,PDCD4,SD,ANOVA,ERK1/2,I/R,SERCA2a
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