Lactobacilli Degrade Wheat Amylase Trypsin Inhibitors to Reduce Intestinal Dysfunction Induced by Immunogenic Wheat Proteins.

Alberto Caminero,Justin L McCarville,Victor F Zevallos,Marc Pigrau,Xuechen B Yu,Jennifer Jury,Heather J Galipeau, Alexandra V Clarizio,Javier Casqueiro,Joseph A Murray,Stephen M Collins,Armin Alaedini,Premysl Bercik,Detlef Schuppan,Elena F Verdu

Gastroenterology（2019）

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摘要

ATI mediate wheat-induced intestinal dysfunction in wild-type mice and exacerbate inflammation to gluten in susceptible mice. Microbiome-modulating strategies, such as administration of bacteria with ATI-degrading capacity may be effective in patients with wheat-sensitive disorders.

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关键词

Microbiome,Bacterial Metabolism,Food Allergy,HLA

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