A UNIQUE PHENOTYPE OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA IN A PATIENT WITH GATA2 DEFICIENCY
PEDIATRIC BLOOD & CANCER(2018)
Abstract
Germline or acquired mutations involving the GATA-binding protein gene (GATA2) have been linked to a variety of clinical conditions. In addition, patients harboring GATA2 mutations have a striking predisposition to develop myeloid malignancies, such as myelodysplastic syndrome or acute myeloid leukemia, but not acute lymphoblastic leukemia (ALL). We report here a unique occurrence of early T-cell precursor ALL in a young child with GATA2 haploinsufficiency.
MoreTranslated text
Key words
deficiency,early T-cell precursor lymphoblastic leukemia,GATA2 transcription factor,pediatrics
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined