Iron-catalyzed alkynylation of tertiary aliphatic amines with 1-iodoalkynes to synthesize propargylamines
Organic Chemistry Frontiers(2018)
Abstract
A method of alkynylation of tertiary aliphatic amines with 1-iodoalkynes has been developed in the presence of FeCl2 as a catalyst and tert-butyl hydroperoxide as an oxidant. With this method, a variety of propargylamines were obtained in good to excellent yields from inexpensive and readily available reagents. The studies on the possible reaction pathway suggest that this reaction proceeds through a radical process.
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Key words
propargylamines,tertiary aliphatic amines,iron-catalyzed
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