SOME TERPENE COMPOUNDS ISOLATED FROM CALLICARPA MACROPHYLLA (L.) SPECIES IN VIETNAM

Callicarpa macrophylla L. (Tu Chau la to) usually used in Vietnam traditional medicine for gastrointestinal bleeding, nosebleeds, in addition, it is also used for treating osteoarthritis pain. Phytochemical investigation of the n -hexan and ethyl acetate extract of Callicarpa macrophylla L. led to the isolation of β- sitosterol ( 1 ), β- sitosterol-3-O- β -D-glucopyranoside ( 2 ), stigmasta-7,22-dien-3 β- ol ( 3 ), β -amyrin ( 4 ), ent -1 α -acetoxy-7 β ,14 α -dihydroxy-kaur-16-en-15-on ( 5 ) va ent -7 β ,16,17,18-tetrahydroxy-kaur-16-en-15-on ( 6 ). Their chemical structures were determined by spectroscopic methods including MS, 1D, 2D NMR and comparing with those reported in previous papers. Three compounds 4, 5, 6 were isolated for the first time from Callicarpa macrophylla  plant.