Abstract 20556: Randomized Controlled Trial of Vitamin D Adjunct Therapy for African American Patients With Left Ventricular Hypertrophy

Introduction: Left ventricular hypertrpophy (LVH) is a consequence of uncontrolled hypertension (HTN). Vitamin D helps regulate multiple, cardiac neurohormonal pathways, and its deficiency may contribute to heart disease. Vitamin D deficiency, HTN, and LVH are all more prevelent among African Americans (AAs); however, few trials have evaluated the direct impact of vitamin D supplementation on LVH in AAs who have uncontrolled HTN. Hypothesis: We hypothesized that, in a cohort of vitamin D deficient AAs with uncontrolled HTN and subclinical hypertensive heart disease, the addition of vitamin D to evidence-based antihypertensive therapy would lead to greater regression of LV mass at one year compared to placebo. Methods: African American patients with uncontrolled HTN (SBP u003e 160 mm Hg), increased LV mass index (LVMI u003e 73 g/m2 for females and u003e 89 g/m2 for males by cardiac MRI [CMR]), and vitamin D deficiency (u003c 20 ng/mL) were randomized to receive antihypertensive therapy plus 50,000 IU vitamin D3 or placebo...