Direct Conversion of Benzyl Ethers into Aryl Nitriles
SYNLETT(2018)
Abstract
A direct method was developed for the conversion of benzyl ethers into aryl nitriles by using NH4OAc as the nitrogen source and oxygen as the terminal oxidant with catalysis by TEMPO/HNO3; the method is valuable for both the synthesis of aromatic nitriles and for the deprotection of ether-protected hydroxy groups to form nitrile groups in multistep organic syntheses.
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Key words
benzyl ethers,aryl nitriles,cyanation,oxidation,organocatalysis
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