Comparison Of Genetic Ancestry Versus Self-Identified Race And Ethnicity As Risk Factor For Intracerebral Hemorrhage

Introduction: Vascular risk factors (VRFs) and their net effects vary across ethnic populations. We hypothesized that use of DNA-based ancestry informative markers (AIMs), compared with self-reported race/ethnicity (SIRE), would result in better prediction of VRFs and thus improve risk modeling in intracerebral hemorrhage (ICH) across U.S. minority populations. Methods: Using data from the Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study (a multi-center case-control study of ICH in whites, blacks, and Hispanics), we utilized 15 AIMs to perform principal component (PC) analysis using variance-standardized relationship matrix dimension reduction. Multivariate logistic regression and tests for independent samples (X2 and Mann-Whitney U tests) were used to compare PC-defined ancestry and SIRE in their association with VRFs, and to estimate effects within each SIRE. Finally, we compared models for ICH risk including AIMs vs. SIRE. Results: Among 4,935 subjects enrolled, 34.7% were blacks, 35....