Therapeutic potential of targeting the Eph/ephrin signaling complex

Nayanendu Saha,Dorothea Robev,Emilia Mason,Juha P. Himanen,Dimitar B. Nikolov

The International Journal of Biochemistry & Cell Biology（2018）

引用 33|浏览11

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摘要

•Eph receptors have emerged as exciting targets for drug development.•3-D structures of Eph/ephrin provide information for therapeutic intervention.•Small molecules and antibodies can intervene with Eph/ephrin signaling.•ADAM metalloproteinases can be inhibited to block Eph activation.

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关键词

RTK,LBD,CRD,FN,SAM,ADAM,Ab,mAb,scFv

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