OP02.02: Placental mesenchymal dysplasia with hepatic mesenchymal hamartoma: a case report: Short oral presentation abstracts

Placental mesenchymal dysplasia (PMD) is a rare placental condition which is characterised by placentomegaly and grapelike vesicles. Although the fetus is phenotypically normal in most reported cases, other fetal abnormalities can often coexist including hepatic mesenchymal hamartomas (HMH). There are only a few reported cases of PMD and associated HMH. We report a rare case of PMD with associated HMH, which resulted in intrauterine fetal death. A 34-year-old G1P0 woman first visited Maternal-fetal Medicine centre of Cheil General Hospital after succeeding pregnancy by intrauterine insemination. At 12 weeks of gestation, thick placenta with multiple anechoic spaces was noticed with normal appearing fetus in first trimester ultrasound scan. Chorionic villus sampling was done in each normal and abnormal appearing placenta. The karyotype in both samples were normal. However, the QF PCR result showed increased ratio of paternal to maternal alleles, indicating androgenetic/biparental mosaicism. As a result, PMD was suspected and close follow up was done. At 27 weeks and 5 days of gestation, thickened placenta with multiple vesicular lesions was still noted and multiple septated cystic masses were noticed in fetal abdomen. Bilateral ovarian cysts were suspected. Aspiration of the cysts was done after 28weeks and 5days of gestation, to reduce the mass effect. However, the complex cysts remained and grew bigger. The patient was transferred to the tertiary centre for further management at 34weeks and 5days but fetal death was confirmed at 36weeks and 6 days of gestation. Termination of pregnancy was done afterward and pathological diagnosis of the placenta confirmed PMD. Autopsy was done for the dead fetus and cystic mesenchymal hamartoma of the liver was confirmed. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.