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Volume effects of radiotherapy on the risk of second primary cancers: A systematic review of clinical and epidemiological studies

Neige Journy,Imène Mansouri,Rodrigue S. Allodji,Charlotte Demoor-Goldschmidt,Debiche Ghazi,Nadia Haddy,Carole Rubino,Cristina Veres,Wael Salem Zrafi,Sofia Rivera,Ibrahima Diallo,Florent De Vathaire

Radiotherapy and Oncology（2019）

Cited 28|Views66
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Abstract
•SPC risks increased with extended fields for Hodgkin lymphoma or childhood cancers.•No included studies estimated normal tissue dose–volume distribution.•Current clinical evidence on possible volume effects on SPC risks is very limited.•Biological mechanisms underlying volume effects on SPC risks are plausible.
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Key words
Radiotherapy,Neoplasms, radiation-induced,Radiation dosage,Dose–response relationship, radiation,Review
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