Impact of Regular Physical Activity on Prognosis After Myocardial Infarction: The OACIS Study

Introduction: It has been demonstrated that regular physical activities improve physical capacities and prognosis in survivor patients with acute myocardial infarction (AMI), especially in well-designed, relatively small patients cohorts. However, impacts of regular physical activity on prognosis are not fully elucidated in large scale, real-world settings because of varieties of confounding factors. Hypothesis: We assessed the hypothesis that regular physical activity at 3-month after AMI is an independent predictor for 5-year survival in a large cohort of post-MI patients registered in the Osaka Acute Coronary Insufficiency Study (OACIS). Methods: The OACIS is a prospective, multicenter, observational study enrolling consecutive patients with AMI at 25 collaborating hospitals in the Osaka region of Japan. Among 8957 patients registered in the OACIS, 5218 patients who reported physical activities at 3-month after MI were enrolled and were followed for 5 years. Multivariate Cox regression was used with th...