Examining the ability of a tau spatial spread metric to indicate disease progression compared to an intensity-based approach

Alzheimers & Dementia(2018)

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Abstract
Figure 2. Voxel-wise mean tau z-score maps relative to young healthy controls are represented for A) amyloid negative CDR 0 older participants, B) amyloid positive CDR 0 participants, and C) amyloid positive CDR > 0 subjects. Results were mapped onto the cortical surface. Z-score of 1.96 represents a statistically significant (p<0.05) difference from controls. Voxel-wise frequency of abnormality maps relative to young healthy controls are represented for D) amyloid negative CDR 0 older participants, E) amyloid positive CDR 0 participants, and F) amyloid positive CDR > 0 subjects. Frequency of abnormality represents the voxel-wise percentage of participants who are abnormal relative to young healthy controls. Austin A. McCullough, Brian A. Gordon, Jon Christensen, Aylin Dincer, Sarah Keefe, Shaney Flores, Russ C. Hornbeck, Randall J. Bateman, John C. Morris, Beau M. Ances, Tammie L. S. Benzinger, Washington University in Saint Louis School of Medicine, St. Louis, MO, USA; Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Washington University School of Medicine, St. Louis, MO, USA; Washington University School of Medicine, Saint Louis, MO, USA; Washington University, St. Louis, MO, USA. Contact e-mail: amccullough@wustl.edu
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Key words
tau spatial,disease progression,spread
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