GW29-e1773 Enhanced oxidative stress mediates pathological autophagy in cardiac myocytes in pressure overload induced heart failure in rats

In cardiac myocytes in vitro, a high concentration of hydrogen peroxide (1 mM) induces myocyte autophagy. Oxidative stress and myocyte autophagy coexist in pressure overload-induced heart failure. In this study, we tested the hypothesis that excessive oxidative stress mediates pathological autophagy