Role of Zeb2/Sip1 in neuronal development

•Mutations in Sip1 cause the Mowat-Wilson syndrome in humans.•Sip1 controls the formation of the hippocampus.•Sip1 is important for cell fate switch in the neocortex development.•Sip1 controls migration of interneurons and is required for the onset of gliogenesis.•Sip1 is needed for axonal growth and branching.