Copper-catalyzed three-component reaction for the synthesis of fluoroalkoxyl imidates

A Cu-catalyzed three-component reaction of aromatic terminal alkynes with aryl sulfonyl azides and primary fluoroalkyl alcohols for the synthesis of fluoroalkoxyl imidates was developed. This simple method enabled the efficient synthesis of trifluoroethoxyl, pentafluoropropoxyl, and heptafluorobutoxyl imidates in good to excellent yields under mild reaction conditions with excellent functional group tolerance.