159. Multiplex analysis of maternal circulating cardiovascular risk biomarkers in preeclampsia

Introduction Preeclampsia is a hypertensive pregnancy disorder that occurs after week 20 of pregnancy, associated with an increased risk for maternal cardiovascular disease (CVD) later in life. The risk is increased with early onset of the disease and delivery of a growth restricted child. The mechanisms underlying these associations are not well established. Objective/hypothesis We aimed to measure the level of circulating biomarkers associated with cardiovascular risk, and hypothesized that the level of these markers at the time of delivery differed between early-onset preeclampsia (EPE), late-onset preeclampsia (LPE) and normotensive controls (NC), as these groups differ in future risk for CVD. Methods The level of 92 biomarkers associated with CVD risk, including markers of inflammation, endothelial function and cardiac stress, were measured in maternal plasma collected at the time of delivery using the Olink Proseek multiplex CVD I assay. The patient group consisted of EPE (n = 37, delivery Results The levels of 82 biomarkers were detectable and included in the data analysis. Using the Kruskal Wallis test, 47 of the biomarkers were found to be significantly different between groups after correction for multiple testing (p  Discussion ST2 is an established marker of endothelial inflammation and cardiac stress, while MMPs have a major function in vascular remodeling and angiogenesis. Altered levels of these markers could indicate specific CVD-related biological processes active mainly in the EPE subtype, potentially linked to the elevated risk of future CVD seen in this group. Future work should assess postpartum levels of the same markers.