Phase 1/2 Precision Medicine Study Of The Next-Generation Braf Inhibitor Plx8394.

Filip Janku,Ulka N. Vaishampayan,Vivek Khemka, Minny Bhatty,Eric J. Sherman,Jessica Tao,Jonathan Whisenant,David S. Hong,Nam Bui,Shivaani Kummar,Lynn G. Feun,Aparna Parikh, Chao Zhang,Glenn Michelson,Eric Martin,Rafe Shellooe,Paul Severson, Michael Pelayo,David A. Karlin,Sunil Sharma

JOURNAL OF CLINICAL ONCOLOGY（2018）

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摘要

2583Background: First-generation BRAF inhibitors (BRAFi) show high response rates and prolonged survival in some BRAFV600-mutant cancers; however, paradoxical activation of the RAF/MEK/ERK pathway ...

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inhibitor,precision medicine study,next-generation

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