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Efficacy Of Pegvorhyaluronidase Alfa (Pegph20) Plus Folfirinox In A Preclinical Model Of Human Pancreatic Ductal Adenocarcinoma.

Jesse Bahn,Feng Gao,Xiaoming Li,Susan Zimmerman,Kelly Chen,Chunmei Zhao,Daniel C. Maneval,Curtis B. Thompson

JOURNAL OF CLINICAL ONCOLOGY（2018）

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Abstract
e16244Background: Hyaluronan (HA) accumulates in the solid tumor microenvironment, and is associated with poor drug penetration and negative clinical outcomes. Pegvorhyaluronidase alfa (P) is a nov...
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human pancreatic ductal adenocarcinoma,pegvorhyaluronidase alfa,pegph20,folfirinox
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