Allometric scaling of preclinical pharmacokinetic and toxicokinetic parameters to predict clinical pharmacokinetics of BXQ-350 saposin C protein-phosphatidylserine nanovesicles.
Journal of Clinical Oncology（2018）
Abstract
e14537Background: Interspecies allometric scaling is used to extrapolate pharmacokinetics (PK) from preclinical data to human PK and dosing. Efficacy of BXQ-350, a novel Saposin C phosphatidylserin...
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Key words
preclinical pharmacokinetics,toxicokinetic parameters,preclinical pharmacokinetic,protein-phosphatidylserine
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