Evaluation of carrier size and surface morphology in carrier-based dry powder inhalation by surrogate modeling
Chemical Engineering Science(2019)
Abstract
•Drug carrier design parameters were evaluated using surrogate modeling.•Image analysis tool was used for surface roughness determination from SEM images.•Important carrier design parameters were identified and models were formulated.•Optimization were performed to provide insights to high fine particle fractions.
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Key words
Dry powder inhalation,Emitted dose,Fine particle fraction,Surface roughness,Variable selection,Artificial neural network,Sensitivity analysis
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