A Retrospective Study Of Curcumin In Combination With Intravenous Vitamin C (Ivc) On Triple Negative Breast Cancer(Tnbc).

e13118Background: TNBC is associated with increased mortality compared to other breast cancer sub-types. There is an urgent need to develop novel, low toxicity and effective therapies for TNBC. Methods: Records of 70 advanced triple negative breast cancer patients treated from July 2012 to July 2017 in our hospital were retrospectively analyzed.35 patients received Gemcitabine{day 1 and day 8, 100mg/m2} + Cisplatin{day2,75mg/m2} (control group) and 35 patients received the above chemotherapy regimen in combination with oral curcumin(500mg/d) and IVC{1g/kg.d, starts from the 3rd day when chemotherapy finished,two times a week, totally 15 treatments}(combination group).The effects of the above treatment methods on tumor size, functional status score, progression free survival and overall survival time were analyzed systematically. Results: By using RECIST 1.1 criteria, 2/35 cases had complete remission (CR), 15/35 cases had partial remission (PR) and 13/35 cases had stable disease (SD) in the treatment grou...