Survival for HPV-positive oropharyngeal squamous cell carcinoma with surgical versus non-surgical treatment approach: A systematic review and meta-analysis

•Systematic review of 73 studies on HPV-positive oropharyngeal carcinoma outcomes.•No meaningful survival difference with surgical versus non-surgical approach.•Absence of high-quality data on survival from surgical versus non-surgical approach.•HPV-positivity remains a key prognostic factor irrespective of treatment modality.