Synthesis and Structure of 2-(4-Heteryl-2-pyrrolidon-1-yl)acetamides

O. S. Vasil’eva,E. S. Ostroglyadov,N. V. Gorodnicheva,S. V. Makarenko,I. N. Tyurenkov,V. N. Perfilova,S. M. Aleksandrova

Russian Journal of General Chemistry（2018）

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摘要

1-Alkoxycarbonylmethyl-4-heteryl-2-pyrrolidones were synthesized by alkylation of 4-heteryl-2-pyrrolidones. 2-(4-Heteryl-2-pyrrolidon-1-yl)acetamides were prepared through the reaction of N -esters with ammonia. The resulting acetamides of 2-pyrrolidones exhibit nootropic properties, antiarrhythmic and antiischemic activity.

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关键词

pyridine, indole, benzimidazole, 2-pyrrolidone, acetamides

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