Photochromotherapy For Treatment Of Hemangiomas In Children.

e23187 Background: This study aims to analyze the clinical effects of noncoherent monochromatic red light emitting diodes on infantile hemangiomas (IH) in children from the new-born to one-and-a half year old for the period from 2004 to 2015. Methods: We investigated the effect of PCT (photochromotherapy) of red spectrum λ = 635 nm with irradiation dose 3·86-3·96 J/cm2 to 2010 children with IH. Results: The results showed a significant regression in 100% of simple IH, in 92% of mixed ones and 84.5% of cavernous forms after PCT. Progression of IH was seen only in 1 patient (0.95%) subjected to tumor destruction. After the first course of PCT, regression of simple and mixed IH forms was registered in half of the patients (49.4 and 50.2% respectively), in cases of cavernous IH – only in 15% of children. Ultrasound control demonstrated reduction of tumors' size in 46-71%, decrease of blood flow in 11-22% and formation of capsule in 40% of the cases. After the second and the third courses of PCT proportion of the patients with regression of IH continued to increase. Decrease of tumors' size was found in 98%, blood flow was weak or absent in 96% of cases, clear borders or capsule were determined in 96% of cases, absence of the tumor-feeding vessels – in 80 cases. VEGF levels in sera of patients with IH before the treatment were 221.1±12 pg/ml, which was 3.1 times higher than in healthy children (72.6±3.2 pg/ml). After effective PCT VEGF levels in patients' sera became close to normal (68.9±2.0 pg/ml). In cases of ulcerative complications of IH the positive local effect of PCT on suppuration and inflammation was observed. The clinical PCT practice allowed the effects of wound healing just after the first course (10 procedures). After the second and third courses (about 25-30 procedures), the significant decrease in tumor size up to the regress and formation of scar was observed. Ultrasound control confirmed the absence of tumor feeding vessels. Conclusions: PCT resulted in wound healing by improving the reduced exudative and epitelisation phases; significant decrease in tumor size up to regress was observed.