Abstract 12358: Epidemiology of Acute Myocardial infarction in Systemic Sclerosis: Incidence and Outcomes

Introduction: Risk of acute myocardial infarction (AMI) in inflammatory arthritides like rheumatoid arthritis (RA) is elevated. However, in autoimmune disorders with microvascular dysfunction, like systemic sclerosis (SS), the risk of AMI and its outcomes are not known. Methods: In the National Inpatient Sample (2003-2012), we used ICD9 codes to identify patients (≥18 years) with a primary diagnosis of AMI and a concurrent diagnosis of SS. We estimated population of SS at risk for AMI during each year by multiplying the previously reported stable SS prevalence of 276/million by the US adult population for the corresponding year. We used survey-analysis to generate national estimates for incident AMI and calculated incidence of AMI among SS patients by dividing the number of AMI patients during each year by the at-risk SS population. Characteristics and outcomes of AMI in SS were compared to those with RA and those without rheumatologic disease. Results: During 2003-2012, there were 4570 admissions for AMI...