Potassium Persulfate-Promoted N-Nitrosation of Secondary and Tertiary Amines with Nitromethane under Mild Conditions
ASIAN JOURNAL OF ORGANIC CHEMISTRY(2018)
Abstract
A simple and efficient route for the N-nitrosation of various secondary amines with nitromethane is described in the presence of potassium persulfate and DBU. Under optimized condition, tertiary amines underwent a dealkylative N-nitrosation with good yields. Inexpensive reagents, broad substrate scope and efficient conversion make the current protocol more attractive in organic synthesis.
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Key words
Potassium Persulfate,N-Nitrosation,Secondary amines,Nitromethane,Oxidation
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