Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Recapitulate Clinical Phenotypes in a Multigenerational Family With Early Onset Atrial Fibrillation and Long Qt Syndrome

Introduction: Early-onset atrial fibrillation (AF) and Long QT Syndrome (LQTS) are associated with gain- and loss-of-function mutations in cardiac potassium channel genes, respectively. Counterintu...