Nav1.7 inhibitors for the treatment of chronic pain
Bioorganic & Medicinal Chemistry Letters（2018）
摘要
•Nav1.7 is a complex protein with multiple druggable sites.•Inhibitors of Nav1.7 are able to produce robust pain relief in preclinical models.•Highly potent and selective (>100×) of Nav1.7 have been recently disclosed.•More work is needed to understand PK/PD relationships of Nav1.7 inhibitors.
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关键词
Nav1.7,SCN9A,Voltage gated sodium channel,Pain
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