Cover Feature: Molecular Tweezers with Additional Recognition Sites (Chem. Eur. J. 44/2018)

Molecular tweezers selectively include lysine and arginine inside their cavities, leading to fascinating biological properties: they prevent pathologic protein aggregation and interfere with protein–protein interactions. This work presents two methods showing how additional arms can be attached to the tweezer body, either with trichloroacetonitrile or with phosphoramidites. If these arms carry terminal alkynes, click chemistry may introduce additional recognition sites and labels for a wide range of applications. More information can be found in the Full Paper by T. Schrader et al. on page 11332.