A New Combination Of Nutraceutics Activates Enos Through Plc/Pkc-Alpha/Akt Signalling

Introduction: Nutraceutics are medicinal foods that in certain components may exert a beneficial effect on cardiovascular system and represent a new opportunity for the maintenance of cardiovascular homeostasis. To date, despite its beneficial effects, the mechanisms involved are not completely clarified. Hypothesis: Here, we aimed to characterize the vascular action of AkP05 (IzzeK®, Akademy Pharma), a new nutraceutic that combines Bacopa monniera, Ginkgo biloba, phosphatidylserine and extract of Green tea leaves in a certain concentration and purification, patent based. Methods: We performed vascular reactivity studies on mice resistance vessels placed on pressure myograph evaluating the effects of increasing doses of AkP05 on phenylephrine-preconstricted vessels. In addition, to characterize the molecular mechanism we performed immunohistochemistry and Western Blot analyses. Results: We demonstrate that AkP05 was able to induce dose-dependent vasodilatation of the mice mesenteric arteries, which was si...