Abstract 17199: Impact of Mean Arterial Pressure on Clinical Outcomes in Comatose Survivors of Out-of-hospital Cardiac Arrest

Background: Comatose survivors of out-of-hospital cardiac arrest (OHCA) are subject to significant morbidity and mortality. Adequate cerebral oxygen delivery is crucial during the early post-arrest period and often compromised by hypotension, cerebrovascular dysregulation, and myocardial dysfunction characterizing the post-cardiac arrest syndrome. Although cerebral perfusion has been hypothesized to be highly dependent on mean arterial pressure (MAP) during the early post-cardiac arrest period, optimal blood pressure targets have not been established. Methods: We identified consecutive patients undergoing targeted temperature management following OHCA secondary to a shockable rhythm (ventricular tachycardia or fibrillation) between August 2010 and July 2013. We then examined the incidence of death and severe neurologic dysfunction (defined as a cerebral performance category (CPC) ≥3) in relation to mean MAP during the first 96 hours of hospitalization. Multivariable logistic regression analyses were used ...