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Tissue optical clearing as a diagnostic tool for tissue pathology differentiation

L.M. Oliveira,I. Carneiro,S. Carvalho,R. Henrique,D.K. Tuchina,P.A. Timoshina,A.N. Bashkatov,E.A. Genina,V.V. Tuchin

2018 INTERNATIONAL CONFERENCE LASER OPTICS (ICLO 2018)（2018）

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Abstract
With the objective of developing a diagnostic tool, we have used the immersion optical clearing method and studied normal and pathological tissues (cancer, diabetes) under treatment by optical clearing agents (OCAs). In order to quantify pathology status OCA diffusion properties in different tissues were measured. We have demonstrated that free water content in cancerous tissues is higher than in normal.
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Key words
optical clearing, free and bound water, diffusion coefficient, pathology diagnosis
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