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A novel molecular chaperone GroEL2 from Rhodococcus ruber and its fusion chimera with nitrile hydratase for co-enhanced activity and stability

Yangzi Chen,Song Jiao,Miaomiao Wang,Jie Chen,Huimin Yu

Chemical Engineering Science（2018）

Cited 9|Views9
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Abstract
•Novel R. ruber chaperones were identified by transcriptome analysis.•R. ruber chaperone GroEL2 was distinguished from conventional GroEL.•GroEL2 showed high self-thermal stability and protection effect on other proteins.•NHase-GroEL2 fusion chimera enhanced the activity of NHase by 63.6%.•It also enhanced thermal stability by 2.9× and acrylamide resistance by 1.1×.
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Key words
Rhodococcus ruber,Nitrile hydratase,Molecular chaperone GroEL2,Fusion expression,Activity and stability
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