Formulation and Evaluation of oral reconstitutable Azithromycin Suspension for the treatment of Bacterial Infection

Azithromycin is used for the treatment of bacterial infection, mainly used in middle ear infection, typhoid, sinusitis, bronchitis in urinary tract infection and venereal disease. The present study aimed to develop dry or oral reconstitutable suspension to minimize the solubility problem of the drug. It shows the adequate chemical stability of the drug during the shelf life and it avoids the problem of physical stability and solubility of drug. The study was carried out by preparing the dry powder or granules for oral reconstitutable suspension by using suspending agent sodium CMC and acacia on release profile of the drug. The prepared best formulation (F6) was selected depending on its physiochemical properties. The prepared oral reconstitutable suspension was evaluated for the rheological, viscosity, re-suspendibility and sedimentation volume. The formulation of acacia showed excellent sedimentation volume and good re-dispersibility as compared to other formulation. The study was found that the dry physical mixture method showed good stability of the drug.