Cute Kidney Injury And Other Factors Associated With Mortality In Hiv- Infected Patients

Background: HIV-related mortality is still high, especially in developing countries. The aim of this study is to investigate factors associated with death in HIV-infected patients. Methods & Materials: This is a cross-sectional study with all HIV adult patients consecutively admitted to a tertiary infectious diseases hospital in Fortaleza, Northeast Brazil, from January 2013 to December 2014. Patients were divided into two groups: survivors and non-survivors. Demographical, clinical and laboratory data were compared and a logistic regression was performed in order to investigate risk factors for death. Results: A total of 200 patients with mean age of 39 years were included in the study, 69.5% males. Fifteen patients (7.5%) died. Non-survivors presented a higher percentage of males (93.3 vs. 67.3%, p = 0.037) and a shorter hospital stay (8 ± 6 vs. 18 ± 15 days, p = 0.005). In multivariate analysis, disorientation (p = 0.035, OR = 5.523), dyspnea (p = 0.046, OR = 4.064), AKI (p < 0.001, OR = 18.045), disseminated histoplasmosis (p = 0.016, OR = 12.696) and lactate dehydrogenase (LDH) > 1000 U/L (p = 0.038, OR = 4.854) were risk factors for death. Conclusion: AKI and disseminated histoplasmosis were the main risk factors for death in the studied population. Neurologic and respiratory impairment as well as higher levels of LDH also increased mortality in HIV-infected patients.