Regioselective Radical Ring Closure of Tertiary Enamides to the Synthesis of Trifluoroethyl‐containing N‐Acyl Isoindoline and N‐Acyl Tetrahydroisoquinoline Derivatives

The regioselectivity of radical addition and cyclization reaction of tertiary enamides between 5‐membered benzoyl group and 5/6/7‐membered benzyl group ring closure was investigated, and trifluoroethyl ‐containing N‐Acyl isoindolines, N‐acyl tetrahydro‐isoquinolines, and N‐benzoyl tetrahydro‐1H‐benzo[c]azepine were obtained in moderate to good yields with high atom economy. Possible reaction pathway for the formation of the products was also discussed in this paper.