Asymmetric synthesis of highly functionalized tyrosine derivatives for the construction of bistetrahydroisoquinoline alkaloids
Tetrahedron Letters（2018）
Abstract
•A highly functionalized l-tyrosine precursor was enantioselectively prepared.•The synthesis of l-tyrosine precursor was realized on a multi-gram scale.•The pentacyclic bistetrahydroisoquinoline skeleton was successfully constructed.
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Key words
Bistetrahydroisoquinoline alkaloid,Tyrosine derivatives,Asymmetric synthesis,l-tyrosine
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