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The Role of Ca 2+ -ATPase 2a ( ATP2A2 ), Ryanodine Receptors ( RYR2 ), and Calsequestrin ( CASQ2 ) Gene Polymorphisms in the Development of Heart Failure

T. Yu. Rebrova,E. F. Muslimova,D. S. Kondratieva,O. V. Budnikova, S. D. Ahmedov,S. A. Afanasiev,S. V. Popov

RUSSIAN JOURNAL OF GENETICS（2018）

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Abstract
This review contains data reflecting the role of polymorphisms and mutations of the genes of proteins Ca 2+ -ATPase 2a, ryanodine receptors, and calsequestrin of the Ca 2+ -transporting system of the sarcoplasmic reticulum of cardiomyocytes in the formation of contractile myocardial dysfunction.
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Key words
heart failure, contractile dysfunction, ATP2A2, RYR2, CASQ2
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