Do Therapeutic Doses of Phenilbutazone Affect Ovulation Processes in Mares

The availability of biochemical blood data specific for the pregnant condition are essential for the correct management of both normal pregnancies and also for the prompt recognition of every abnormality. Because of the lacking knowledge about biochemical blood analysis in the donkey along the entire pregnancy, the study was designed to provide first preliminary data about the values and possible changes of blood alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), alkaline phosphatase (ALP), creatine-kinase (CK), blood urea nitrogen (BUN), creatinine (CREA), uric acid (UA), amylase (AMY), gamma-glutamyl transferase (γ-GT), triglycerides (TRI), cholesterol (CHOL), total protein (TP), albumin (ALB), glucose (GLU), phosphorus (P), calcium (Ca), occurring from the beginning of pregnancy until parturition. The study was performed on 10 Martina Franca healthy jennies with normal pregnancy course and giving birth to mature, healthy and viable foals. Blood samples were collected monthly from the 1st to the 6th month of pregnancy, then twice a month from the 6th to the 9th month and afterwards weekly until parturition. The results showed a significant slight increase of glucose and creatinine in the second quarter of pregnancy and a minor decrease of cholesterol near to parturition, while all the other parameters did not significantly change along pregnancy.