Zeolite-encapsulated Mn(II) complex: A new nano catalyst for the synthesis of modafinil and its derivatives

The Mn-hydrazone Schiff base encapsulated into NaY has been prepared and characterized as a new heterogeneous catalyst. Elemental analysis, UV-Vis, infrared spectroscopic analysis, diffused reflectance spectroscopy, thermal analysis, small angle X-ray diffraction, and N-2 sorption demonstrate the existence of Mn-hydrazone schiff base in the nanopores of zeolite-Y. Mn-II(Hsal- hrz)/Y, which showed excellent catalytic property in oxidation with various sulfide compounds including important drugs such as adrafinil and modafinil, using hydroperoxide-urea (UHP) as oxidant. Thioanisole conversion was high (98%).