Importance of target-mediated drug disposition for small molecules

Dennis A. Smith,Robert van Waterschoot,Neil Parrott,Andrés Olivares-Morales,Thierry Lavé,Malcolm Rowland

Drug Discovery Today（2018）

引用 14|浏览11

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摘要

•Target-mediated drug disposition for small molecules is not addressed systematically.•TMDD has a major influence on drug distribution and clearance.•TMDD results in unpredictable and non-linear pharmacokinetics.•TMDD confounds human microdosing approaches.

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