Effect of Endurance Training on Vaspine and Glycemic Indexes in Diabetic Rats

Background and Objectives: Vaspin is an adipokine, which has been derived from and recognized in the visceral fat tissue in rat. In the present study, the effect of endurance training was investigated on vaspin and glycemic indexes of diabetic rats. Methods: In this experimental study, 45 Sprague-Dawley rats were made diabetic by streptozotocin toxin after one week adaptation to laboratory conditions. In the following, after measuring fasting glucose of rats, 30 rats with fasting glucose above 200mg/dl, were selected as statistical sample and randomly divided into three groups (moderate and high intensity training and control). Moderate and high intensity training groups respectively ran on treadmill with no slope for 6 weeks (three 20 minute sessions per week) with the speed of 8-12m/min and 12-18m/min. Data were analyzed using statistical tests of Kolmogorov-Smirnov, one-way ANOVA, and Tukey post-hoc tests. The level of significance was considered as p<0.05. Results: In this study, high-intensity training has a significant effect on the increase of vaspin. Moderate and high intensity training also had significant effects on the reductions of insulin, fasting glucose, and insulin resistance in diabetic rats. Conclusion: According to the findings of the present research, it was clarified that endurance training can significantly affect glycemic indexes in diabetic rats.