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Highly regioselective 4-hydroxy-1-methylpiperidine mediated aromatic nucleophilic substitution on a perfluorinated phthalimide core

Ramóna Madácsi,Márió Gyuris,János Wölfling,László G. Puskás,Iván Kanizsai

Journal of Fluorine Chemistry（2018）

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Abstract
•1-Methyl-4-hydroxypiperidine mediated highly regioselective SNAr protocol was developed.•The inherent regioselectivities were modified towards the less favoured bioactive regioisomer.•The optimal condition could be utilized for gram scale synthesis.
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Key words
Aromatic nucleophilic substitution,SNAr,Phtalimide,Regioselective,Tertiary amine
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