Regulation of transcription factors in the ER stress recognition system during acute pancreatits

The effect of biodegradation on adamantanes has been studied, based on a suite of genetically related crude oils with increasing degree of biodegradation, from the Miaoxi Depression, Bohai Bay Basin, China. Selectivity during biodegradation was observed for the adamantanes. The relative susceptibility to biodegradation of individual adamantane compounds was determined based on their compositional changes. Adamantanes with more alkyl substituents were generally more resistant to biodegradation, but exceptions also occurred. The position of alkylation had great control on the susceptibility to biodegradation. However, the more thermally stable compounds were not always more readily biodegraded, suggesting that the susceptibility of adamantanes is not directly controlled by thermodynamic stability. Selective biodegradation of adamantanes may be related to their stereochemical structures and demethylation could have occurred. Microbial alteration of adamantanes had negligible effects on the methyladmantane index, dimethyladamantane index 1, dimethyladamantane index 2, trimethyladamantane index 1 and trimethyladamantane index 2, suggesting that they could still be used to evaluate the thermal maturity of biodegraded crude oils. In contrast, the ethyladmantane index was significantly altered and thus is not valid for maturity assessment of biodegraded oils.