Towards the structural characterization of the human methyltransferome

Current Opinion in Structural Biology（2018）

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摘要

•Methyltransferases (MTases) are structurally aligned and classified.•Structures of the human methyltransferome are tabulated.•New complexes show histone readers and epigenetic mechanisms of MTase activation.•MTase-activator complexes show mechanisms of MTase activation beyond chromatin.

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structural characterization

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