Effect Of Supplementation Of Fruit Extract (Cranberrry, Blueberry And Pomegranate) On Insulin Resistance And Oxidative Stress In Hypertensive Patients

Objective: The purpose of this study was to determine if antioxidants (fruit extract) supplementation interfere with insulin resistance and oxidative stress in hypertensive patients. Design and method: A clinical trial was conducted with 59 individuals, 30 hypertensive patients (group A) and 29 normotensive controls (group B). Study participants received placebo capsules for 4 weeks and then received the fruit extract capsules (blueberry, cranberry and pomegranate), one capsule each day for 4 weeks. Oxidative stress was evaluated by the catalase, TBARS, SOD, carbonyl and FRAP methods. Anthropometric assessment (weight, height, and body mass index), systolic BP, diastolic BP, heart rate, and biochemistry were evaluated at baseline, after 4, and 8 weeks. The comparisons between groups were held with the GLM repeated measures. Results: The mean age among hypertensive participants was 49.3 ± 9.3 years, of which 33 (55.9%) were female. BMI, blood pressure and heart rate did not differ between groups. HOMAir decreased significantly in both groups. Oxidative stress analysis showed increased catalase in both groups and reduced TBARs, carbonyl, and FRAP in the hypertensive group.Conclusions: The results of this study suggest that supplementation with fruit capsules rich in antioxidants for 4 weeks significantly reduces insulin resistance and improves oxidative stress in hypertensive patients.