Antitumor activity of Pinoresinol in vitro: Inducing apoptosis and inhibiting HepG2 invasion

Pin exhibits significant suppression on the growth of hepatoma cells in vitro. These effects were largely mediated via apoptosis associated with mitochondrial-mediated intrinsic pathways and the death receptor-mediated extrinsic pathway, as well as the disturbance of tubulin polymerization dynamics. In addition, Pin treatment increased the expression of E-cadherin and decreased the expression of VCAM-1, ICAM-1 and MMP-9 may also contribute to its function of anti-migration and invasion.