High throughput single cell sequencing of both T-cell-receptor-beta alleles

Tomonori Hosoya,Hongyang Li,Chia-Jui Ku,Qingqing Wu,Yuanfang Guan,James Douglas Engel

bioRxiv（2018）

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摘要

Allelic exclusion is a vital mechanism for the generation of monospecificity to foreign antigens in B- and T-lymphocytes. Here we developed a high-throughput barcoded method to simultaneously analyze the VDJ recombination status of both T cell receptor beta alleles in hundreds of single cells using Next Generation Sequencing.

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