EFFECTS OF LOW-DOSE ASPIRIN ADMINISTRATION ON CIRRHOSIS-RELATED THROMBOCYTOPENIA

PLTs<150.000 had 73(67.6%),and <110000 had 40(37%) of patients.LS>20kPa was observed in 56(51.9%)and >25kPa in 35(32.4%).In our cohort, BAVENO VI criteria could predict the absence of HRV with sensitivity and NPV of 100%.12/59(20.3%)could avoid UGE.No patient with HRV full filled the BAVENO VI criteria for non-screening endoscopy.Adopting the expanded criteria, 52(48%) supposed not to undergo screening UGE.Among them 10(9.26%)had HRV.Sensitivity was 80.8% and NPV 60% (p=0.372).When PLTs replaced by spleen diameter<13cm, 31/108(28.7%)would avoid screening UGE.Only 1 patient with HRV was misclassified in the non-endoscopy group.Sensitivity was 96.8% and NPV 96% (p=0.001).Conclusions: Our study validated the predicting value of BAVENO VI criteria even if only 20% of cirrhotics could safely skipped screening UGE.The expanded criteria couldn't be validated, showing high rate of misclassification among patients with HRV.Replacing PLTs by spleen diameter, could safely avoid screening UGE at 28.7%, with minimal possibility patients with HRV to be missed. Tu1559